Search results for " human [supplementary concept]"

showing 10 items of 1361 documents

Does Pasteurized Donor Human Milk Efficiently Protect Preterm Infants Against Oxidative Stress?

2019

International audience; Pasteurized donor human milk (DHM) is the preferred alternative for infant nutrition when own mother's milk (OMM) is unavailable. Whether DHM is an efficient means for protecting preterm infants from oxidative stress remains unknown. We quantified a panel of oxidative stress biomarkers in urine samples from preterm infants (≤32 weeks of gestation and a birth weight ≤1500 g) receiving ≥80% of feeding volume as either DHM or OMM. The noninvasive in vivo assessment of oxidative stress showed no statistically significant difference between both groups at the time when full enteral nutrition (150 mL/kg body weight) was achieved and until hospital discharge. In addition, t…

0301 basic medicinePhysiology[SDV]Life Sciences [q-bio]Clinical BiochemistryPasteurizationmedicine.disease_causeBiochemistrylaw.inventionpreterm infant03 medical and health sciencesEnteral Nutritionfluids and secretionslawHumansMedicineoxidative stressLongitudinal StudiesProspective StudiesFood scienceMolecular BiologyGeneral Environmental Science2. Zero hungerMilk Human030102 biochemistry & molecular biologyfull enteral feedingbusiness.industryInfant Newbornfood and beveragesbiomarkersInfant nutritionCell BiologyInfant Low Birth Weight3. Good health030104 developmental biologydonor human milk (DHM)own mother's milk (OMM)PasteurizationGeneral Earth and Planetary SciencesFemalebusiness[SDV.AEN]Life Sciences [q-bio]/Food and NutritionInfant PrematureOxidative stress
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Cabozantinib targets bone microenvironment modulating human osteoclast and osteoblast functions

2016

Cabozantinib, a c-MET and vascular endothelial growth factor receptor 2 inhibitor, demonstrated to prolong progression free survival and improve skeletal disease-related endpoints in castration-resistant prostate cancer and in metastatic renal carcinoma. Our purpose is to investigate the direct effect of cabozantinib on bone microenvironment using a total human model of primary osteoclasts and osteoblasts.Osteoclasts were differentiated from monocytes isolated from healthy donors; osteoblasts were derived from human mesenchymal stem cells obtained from bone fragments of orthopedic surgery patients. Osteoclast activity was evaluated by tartrate resistant acid phosphatase (TRAP) staining and …

0301 basic medicinePyridines -- pharmacologyPyridinesPyridineImmunoenzyme TechniqueOsteoclastsApoptosisRANK Ligand -- genetics -- metabolismImmunoenzyme Techniqueschemistry.chemical_compoundBone Resorption -- drug therapy -- metabolism -- pathology0302 clinical medicineOsteogenesisCathepsin KMedicineAnilidesAnilides -- pharmacologyOsteoprotegerin -- genetics -- metabolismOsteoclasts -- cytology -- drug effects -- physiologyHuman primary cellCells CulturedTartrate-resistant acid phosphataseReceptor Activator of Nuclear Factor-kappa B -- genetics -- metabolismbiologyProto-Oncogene Proteins c-met -- genetics -- metabolismReceptor Activator of Nuclear Factor-kappa BReverse Transcriptase Polymerase Chain ReactionOsteoblastOsteogenesiOsteoblastCell DifferentiationSciences bio-médicales et agricolesProto-Oncogene Proteins c-metOsteoblasts -- cytology -- drug effects -- physiologymedicine.anatomical_structureCell Differentiation -- drug effectsOncologyRANKL030220 oncology & carcinogenesishuman primary cellsOsteoclastosteoprotegerin (OPG)bone microenvironmentHumanResearch Papermusculoskeletal diseasesmedicine.medical_specialtyCabozantinibBlotting WesternOsteogenesis -- drug effects -- physiologyReal-Time Polymerase Chain ReactionBone resorption03 medical and health sciencesOsteoprotegerinOsteoclastcabozantinibInternal medicineHumansRNA MessengerBone ResorptionCell ProliferationOsteoblastsbusiness.industryRANK LigandAnilideOsteoprotegerinApoptosiBone microenvironment; Cabozantinib; Human primary cells; Osteoprotegerin (OPG); Receptor activator of nuclear factor-kb ligand (RANKL); Anilides; Apoptosis; Blotting Western; Bone Resorption; Cell Differentiation; Cell Proliferation; Cells Cultured; Humans; Immunoenzyme Techniques; Osteoblasts; Osteoclasts; Osteogenesis; Osteoprotegerin; Proto-Oncogene Proteins c-met; Pyridines; RANK Ligand; RNA Messenger; Real-Time Polymerase Chain Reaction; Receptor Activator of Nuclear Factor-kappa B; Reverse Transcriptase Polymerase Chain Reaction; Oncology030104 developmental biologyEndocrinologychemistrybiology.proteinbusinessRNA Messenger -- geneticsreceptor activator of nuclear factor-kb ligand (RANKL)
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Iron-loaded transferrin (Tf) is detrimental whereas iron-free Tf confers protection against brain ischemia by modifying blood Tf saturation and subse…

2018

Despite transferrin being the main circulating carrier of iron in body fluids, and iron overload conditions being known to worsen stroke outcome through reactive oxygen species (ROS)-induced damage, the contribution of blood transferrin saturation (TSAT) to stroke brain damage is unknown. The objective of this study was to obtain evidence on whether TSAT determines the impact of experimental ischemic stroke on brain damage and whether iron-free transferrin (apotransferrin, ATf)-induced reduction of TSAT is neuroprotective. We found that experimental ischemic stroke promoted an early extravasation of circulating iron-loaded transferrin (holotransferrin, HTf) to the ischemic brain parenchyma.…

0301 basic medicineU-PAGE urea-polyacrylamide gel electrophoresisMaleClinical BiochemistryExperimental strokeBiochemistryBrain IschemiaBrain ischemia0302 clinical medicineADC apparent diffusion coefficientApotransferrinDWI diffusion-weighted imagingTANDEM-1 Thrombolysis and Deferoxamine in Middle Cerebral Artery Occlusion clinical trialrHTf rat HTfrATf rat ATflcsh:QH301-705.5chemistry.chemical_classificationNeuronslcsh:R5-920ChemistryTransferrinExtravasationNS21 a medium supplement to grow neuronspDAPK-1 phosphorylated anti-death-associated protein kinase 1NeuroprotectionStrokeWB Western blotFemalemedicine.symptomlcsh:Medicine (General)Research PaperhHTf human HTfPC12 cell line derived from a pheochromocytoma of the rat adrenal medullamedicine.medical_specialtyIron OverloadBBB blood-brain barrierNMDAR N-methyl-D-aspartate receptorDCF dihydrofluoresceinIronWGA wheat germ agglutininHTf holotransferrinTransferrin receptorBrain damageTfR transferrin receptorDeferoxamineNeuroprotectionPI propidium iodide03 medical and health sciencesBrain damageCM conditioned mediumROS reactive oxygen speciesInternal medicine4-HNE 4-hydroxynonenalTf transferrinReceptors TransferrinmedicineFeRhoNoxTM-1 probe to detect Fe2+AnimalsHumansATf apotransferrinCM-H2DCFDA 5-chloromethyl-27-dichlorodihydrofluorescein diacetateMCAO middle cerebral artery occlusionDMT-1 divalent metal transporterB-27 a medium supplement to grow neuronsReactive oxygen speciesNMDA N-methyl-D-aspartateTSAT blood transferrin saturationTransferrin saturationBlood transferrin saturation (TSAT)Organic ChemistryNIR near infraredReactive oxygen species (ROS)medicine.diseasepMCAO permanent middle cerebral artery occlusionRatsPWI perfusion-weighted imaging030104 developmental biologyEndocrinologylcsh:Biology (General)TransferrinDAPK-1 anti-death-associated protein kinaseOGD oxygen/glucose deprivationTTC 235-triphenyl-tetrazolium chlorideLipid PeroxidationMCA middle cerebral arteryApoproteinsReactive Oxygen SpeciesMRI magnetic resonance imagingtMCAO transient middle cerebral artery occlusion030217 neurology & neurosurgeryhATf human ATf
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C3 Drives Inflammatory Skin Carcinogenesis Independently of C5

2021

Nonmelanoma skin cancer such as cutaneous squamous cell carcinoma (cSCC) is the most common form of cancer and can occur as a consequence of DNA damage to the epithelium by UVR or chemical carcinogens. There is growing evidence that the complement system is involved in cancer immune surveillance; however, its role in cSCC remains unclear. Here, we show that complement genes are expressed in tissue from patients with cSCC, and C3 activation fragments are present in cSCC biopsies, indicating complement activation. Using a range of complement-deficient mice in a two-stage mouse model of chemically-induced cSCC, where a subclinical dose of 7,12-dimethylbenz[a]anthracene causes oncogenic mutatio…

0301 basic medicineWT wild typeSkin NeoplasmsComplement receptorComplement Membrane Attack Complexmedicine.disease_causeBiochemistrychemistry.chemical_compoundMice0302 clinical medicineCR complement receptorComplement ActivationSkinMice KnockoutcSCC cutaneous squamous cell carcinomaComplement C5Complement C3Receptors Complement030220 oncology & carcinogenesisCarcinoma Squamous CellDisease ProgressionTumor BiologyOriginal ArticleMAC membrane attack complexSignal TransductionHPV16 human papillomavirus type 16910-Dimethyl-12-benzanthraceneTPA 12-O-tetradecanoylphorbol-13-acetateMice TransgenicDermatologySettore MED/08 - Anatomia Patologica03 medical and health sciencesmedicineAnimalsHumansC3Molecular BiologyReceptor Anaphylatoxin C5aDMBA 712-dimethylbenz[a]anthracenebusiness.industry712-Dimethylbenz[a]anthraceneCancerCell BiologyNeoplasms Experimentalmedicine.diseaseComplement systemDisease Models Animal030104 developmental biologychemistryTumor progressionCancer researchCarcinogensTumor EscapeSkin cancerbusinessCarcinogenesisComplement membrane attack complexSkin carcinogenesis.EC epithelial cell
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Dysregulation of C-X-C motif ligand 10 during aging and association with cognitive performance

2017

International audience; Chronic low-grade inflammation during aging (inflammaging) is associated with cognitive decline and neurodegeneration; however, the mechanisms underlying inflammaging are unclear. We studied a population (n = 361) of healthy young and old adults from the MyoAge cohort. Peripheral levels of C-X-C motif chemokine ligand 10 (CXCL10) was found to be higher in older adults, compared with young, and negatively associated with working memory performance. This coincided with an age-related reduction in blood DNA methylation at specific CpGs within the CXCL10 gene promoter. In vitro analysis supported the role of DNA methylation in regulating CXCL10 transcription. A polymorph…

0301 basic medicinegamma interferon inducible protein 10genomic DNAAlzheimerin tautiEpigenesis GeneticCohort StudiesCXCL10 geneCognitionsingle nucleotide polymorphismcognitive defectCognitive declineAged 80 and overCerebral Cortexeducation.field_of_studyprefrontal cortexDNA methylationGeneral NeuroscienceadultNeurodegenerationneurodegenerationta3141U937 CellsMethylationta3142Alzheimer's diseasecohort analysisDNA-metylaatioagedfemalepriority journalepigenetiikkaDNA methylationAlzheimer's diseaseAlzheimer diseasetranscription regulationAlzheimer’s diseasekognitiiviset taidotmedicine.medical_specialty[SDV.MHEP.AHA] Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO]in vitro studyAdolescentheredityPopulationBiologyArticleworking memoryYoung Adult03 medical and health sciencesCognitive agingpromoter regionmaleMemoryInternal medicineJournal Articlemedicine[SDV.MHEP.AHA]Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO]HumansCXCL10controlled studyEpigeneticshumanbrain levelNeurodegenerationeducationepigeneticscognitive aginghuman cellagingdisease associationmedicine.diseasemajor clinical studyInflammagingChemokine CXCL10gamma interferon inducible protein 10; genomic DNA adult; age; aged; aging; Alzheimer disease; Article; brain level; cognitive defect; cohort analysis; controlled study; CpG island; CXCL10 gene; disease association; DNA methylation; epigenetics; female; heredity; human; human cell; in vitro study; inflammation; major clinical study; male; prefrontal cortex; priority journal; promoter region; single nucleotide polymorphism; transcription regulation; working memory; Alzheimer's disease; Cognitive aging; DNA methylation; Epigenetics; Inflammaging; Neurodegeneration030104 developmental biologyEndocrinologyikääntyminenageinflammationNerve DegenerationCpG islandinflammagingNeurology (clinical)Geriatrics and GerontologyHeLa CellsDevelopmental BiologyNeurobiology of Aging
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From critters to cancers: bridging comparative and clinical research on oxygen sensing, HIF signaling, and adaptations towards hypoxia

2011

The objective of this symposium at the First International Congress of Respiratory Biology (ICRB) was to enhance communication between comparative biologists and cancer researchers working on O(2) sensing via the HIF pathway. Representatives from both camps came together on August 13-16, 2006, in Bonn, Germany, to discuss molecular adaptations that occur after cells have been challenged by a reduced (hypoxia) or completely absent (anoxia) supply of oxygen. This brief "critters-to-cancer" survey discusses current projects and new directions aimed at improving understanding of hypoxic signaling and developing therapeutic interventions.

0303 health sciencesbusiness.industryHypoxia (environmental)610 Medicine & healthPlant Science10081 Institute of Veterinary Physiology3. Good health03 medical and health sciences0302 clinical medicine030220 oncology & carcinogenesisInternational congress10076 Center for Integrative Human Physiology1110 Plant ScienceMedicine570 Life sciences; biologyAnimal Science and Zoology1103 Animal Science and ZoologybusinessOxygen sensingNeuroscience030304 developmental biology
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2020

Mediators of change in online acceptance and commitment therapy for psychological symptoms of parents of children with chronic conditions : An investigation of change processes

050103 clinical psychologyOrganizational Behavior and Human Resource ManagementHealth (social science)05 social sciencesAcceptance and commitment therapy030227 psychiatry03 medical and health sciencesBehavioral Neuroscience0302 clinical medicine0501 psychology and cognitive sciencessense organsskin and connective tissue diseasesPsychologyApplied PsychologyEcology Evolution Behavior and SystematicsClinical psychologyJournal of Contextual Behavioral Science
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Developmental trajectories of experiential avoidance and depressive symptoms and association to health behaviors among adolescents during brief guide…

2021

Abstract While many children and adolescents experience psychological problems with up to 20 percent estimated to develop a mental health problem, only few receive treatment. Online interventions can help respond to the need of support among young people without requiring considerable resources. However, relatively few studies have examined the efficacy of online interventions for youth and more research is needed to understand individual differences in benefiting from these interventions. The current study sought to examine different developmental trajectories of experiential avoidance and depressive symptoms and their association to health behaviors measured at baseline during a brief gui…

050103 clinical psychologyOrganizational Behavior and Human Resource ManagementHealth (social science)05 social sciencesPsychological interventionContext (language use)medicine.diseaseAcceptance and commitment therapyMental health3. Good health030227 psychiatrySubstance abuse03 medical and health sciencesBehavioral Neuroscience0302 clinical medicineIntervention (counseling)medicineExperiential avoidance0501 psychology and cognitive sciencesAssociation (psychology)PsychologyApplied PsychologyEcology Evolution Behavior and SystematicsClinical psychologyJournal of Contextual Behavioral Science
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The Youth Compass -the effectiveness of an online acceptance and commitment therapy program to promote adolescent mental health: A randomized control…

2021

Abstract Purpose Mental health problems affect 10-20% of adolescents worldwide. Prevention and early interventions for promoting adolescent mental health are therefore warranted. The aim of this randomized controlled trial was to examine the effects of a 5-week web-intervention (Youth COMPASS) based on the principles of Acceptance and Commitment Therapy on adolescents’ depressive symptoms, life satisfaction and psychological flexibility. Methods The sample comprised 243 adolescents at the age of 15-16 years (51%females) from 15 lower secondary schools. Participants were randomly assigned to three groups of which two groups received an ACT-based online-intervention including support via What…

050103 clinical psychologyOrganizational Behavior and Human Resource ManagementHealth (social science)05 social sciencesPsychological interventionLife satisfactionFlexibility (personality)Affect (psychology)Mental healthAcceptance and commitment therapy030227 psychiatrylaw.invention03 medical and health sciencesBehavioral Neuroscience0302 clinical medicineRandomized controlled triallawIntervention (counseling)0501 psychology and cognitive sciencesPsychologyApplied PsychologyEcology Evolution Behavior and SystematicsClinical psychologyJournal of Contextual Behavioral Science
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Competence and adherence in an acceptance and values-based intervention: Effects on treatment outcome and early changes in depression

2020

Abstract Background The present study investigated competence and adherence in an acceptance- and values-based intervention and their impact on the outcomes of treatment and early changes in depression. Method A total of 74 sessions delivered by novice therapists (n = 37) were rated for overall competence and adherence to treatment manual, as well as for process-specific components of acceptance and commitment therapy (ACT) using the ACT Adherence Scale (Plumb & Vilardaga, 2010). The relationships between (a) competence and adherence, (b) treatment outcome, and (c) early therapeutic changes among patients diagnosed with major depressive disorder (n = 37) were explored. Results Higher compet…

050103 clinical psychologyOrganizational Behavior and Human Resource ManagementHealth (social science)05 social sciencesTreatment outcomePsychological interventionIntervention effectmedicine.diseaseAcceptance and commitment therapy030227 psychiatry03 medical and health sciencesBehavioral Neuroscience0302 clinical medicinemedicineMajor depressive disorder0501 psychology and cognitive sciencessense organsskin and connective tissue diseasesPsychologyCompetence (human resources)Applied PsychologyEcology Evolution Behavior and SystematicsDepressive symptomsClinical psychologyJournal of Contextual Behavioral Science
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